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By Charles M. Gaitz M.D. (auth.), Charles M. Gaitz (eds.)

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The lipofuscin bodies of the 30-month-old mouse contain many dense crystal-like particles (arrows). Some of the mitochondria of the older animal appear larger and more irregular in outline than the mitochondria in the ganglion cell of the young animal. X 16,200 and X 17,000, left to right; insert X 120,000. (From Samorajski, Drdy, and Rady Reimer 1968) 48 T. Samorajski andJ. M. Ordy represent the only abnormal form of lipid present in brain of aging subjects. The functional significance of lipofuscin pigment accumulation in neonatal tissue has not been clarified, however, and attempts to isolate pigment from human brain have not been entirely successful.

5 percent of the whole sample was a brain syndrome successfully predicted. These findings seem to suggest that some other factor in addition to age-related change is necessary to create the conditions for a fully developed chronic brain syndrome. 26 D. W. K. Kay Some Implications of Epidemiological Studies and Future Research Organic brain disease in the aged is closely related to the biological processes that result in aging and death, which is one cogent reason for concentrating effort in this area.

1962. The Significance of Affective Symptoms in Old Age. London: Oxford University Press. R. 1962. Psychological Illness: A Community Study. London: Tavistock Publications. Roth, M. 1955. The natural history of mental disorders arising in the senium. J. Ment. Sci. 101:281. Roth, M. 1971. Classification and aetiology in mental disorders of old age: some recent developments. In Recent Developments in Psychogeriatrics. K. Kay and A. ). ): Headley Bros. , and Malamud, N. 1965. Comparison of clinical and neuropathological findings in geriatric mental illness.

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